Panchakarma is a traditional Ayurvedic detoxification and rejuvenation approach that is increasingly discussed in the context of chronic disease management. It involves a structured set of therapies aimed at eliminating accumulated toxins, restoring physiological balance, and improving overall functional health. Common procedures include therapeutic emesis, purgation, medicated enemas, nasal therapies, and bloodletting, often preceded by preparatory and post-therapy regimens. In chronic conditions such as metabolic disorders, musculoskeletal diseases, and stress-related illnesses, Panchakarma is used as an adjunct to improve symptom control, enhance well-being, and support lifestyle modification. When integrated with modern medical care, it may contribute to holistic, patient-centered management strategies while emphasizing individualized treatment and long-term preventive health.