Rasaushadhi formulations, used in traditional Ayurvedic practice, may contain processed metals, minerals, and other ingredients that require careful quality control and safety evaluation. Improper preparation, contamination, incorrect dosing, or prolonged use can increase the risk of toxicity, particularly involving the liver, kidneys, and nervous system. Safe clinical use requires attention to source verification, manufacturing standards, appropriate testing, patient selection, and ongoing monitoring. Assessment may include relevant laboratory investigations and evaluation for potential drug interactions and adverse effects. Understanding traditional processing methods alongside modern toxicological principles is essential for informed clinical decision-making. Evidence-based safety protocols, transparent product composition, and timely recognition of toxicity are crucial to protecting patients and promoting responsible integrative healthcare.