Shodhana Chikitsa is a fundamental bio-purificatory approach in Ayurveda aimed at eliminating accumulated doshas and restoring physiological balance. Its practical application in daily clinical practice involves careful patient selection based on roga-rogi pariksha (disease and patient assessment), followed by appropriate preparatory measures (Purva Karma), the selected purification procedure (Pradhana Karma), and post-procedure care (Paschat Karma). Depending on the indication, therapies such as Vamana, Virechana, Basti, Nasya, and Raktamokshana may be employed to manage chronic metabolic, musculoskeletal, dermatological, and gastrointestinal disorders. Individualized treatment planning, adherence to classical Ayurvedic principles, and appropriate dietary and lifestyle recommendations are essential to optimize therapeutic outcomes and minimize complications.